Single Molecule Spectroscopy and Molecular Motors.
David Bensimon is CNRS director of Research at the Laboratoire de Physique Statistique of the Ecole Normale Superieure in Paris. His main interests are the study of DNA and DNA/protein interactions. That research, which started in 1992, led to the development of magnetic tweezers adn the discovery of molecular combing and P-DNA, the structure adopted by DNA at large positive torques. He and his research colleagues have contributed to a more detailed understanding of the interactions between DNA and topisomerases (the enzymes that disentangle DNA), helicases (the enzymes that open up the double helix), DNA polymerases (responsible for the replication of DNA), and a variety of DNA translocases (FtsK, chromatine remodeling factors, etc.).